Postdoctoral Researcher

UHN is Canada's #1 hospital and the world's #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN's vision is to build A Healthier World and it's only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

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Union: Non-Union
Site: Toronto Western Hospital - Krembil Research Institute
Department: Krembil Brain Institute - Division of Experimental & Translational Neuroscience
Reports to: Principal Investigator
Work Model: On-site
Grade: V0:90
Hours: 37.5 hours per week
Salary Range: $53,303 - $69,293 annually (To commensurate with experience and consistent with UHN compensation policy)
Shifts: Day
Status: Temporary Full-Time (to December 2026)
Closing Date: February 28, 2025

Position Summary: Several postdoctoral positions are available for synthetic organic or medicinal chemists within a small molecule therapeutics group at the Krembil Research Institute, UHN. You will be part of a multi-disciplinary team tasked with translating new biological discoveries into druggable targets. The position will be focused on multi-step syntheses of novel small molecules that will be tested in various biological assays conducted within laboratories of PI's at Krembil, Princess Margaret, and UHN. The successful candidate will join a vibrant multi-disciplinary academic research group consisting of over 30 biochemists, molecular biologists, behavioural neuroscientists, computational chemists, and medicinal chemists.

• Design and synthesize new chemical entity small molecules as putative drug platforms
• Conduct multi-step syntheses of small molecules using state-of-the-art synthetic organic chemistry methods
• Conduct structure- and ligand-based design and basic molecular modelling
• Work collaboratively with expert researchers across a multitude of disease biology areas and other scientific disciplines
• Conduct due diligence on potential therapeutic target

• Ph.D. in synthetic organic chemistry, medicinal chemistry, or related field
• Expertise and experience in standard techniques of synthetic organic chemistry
• Effective team player with strong collaborative troubleshooting skills
• Experience working in multi-disciplinary teams is an asset
• Solid documentation skills and organizational ability
• Excellent communication and presentation skills
• Basic knowledge of key concepts in biochemistry and pharmacology an asset

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.